Loxidol
(Meloxicam)




COMPOSITION

Each ampoule contains meloxicam 15 mg.

THERAPEUTIC INDICATIONS

- Rheumatoid arthritis;
- Degenerative joint disease;
- Spondylitis (Bechterew disease).

CONTRAINDICATIONS

- Hypersensitivity to meloxicam (including other nonsteroidal anti-inflammatory agents) or other drug compounds;
- Gastric ulcer or duodenal ulcer in phase of exacerbation and during not less than 6 month after it;
- Chronic renal impairment in patients not underwent by hemodialysis;
- Severe liver impairment;
- Infancy and adolescence under 15;
- Bleedings (including bleedings from GIT), apoplexy;
- Pregnancy;
- Lactation (breast feeding);
- Allergic reactions (bronchial asthma, recurrent nasal and paranasal sinuses polyposis, Quincke's edema, urticaria) on acetylsalicylic acid other nonsteroidal anti-inflammatory agents;
- Hypersensitivity to acetylsalicylic acid other nonsteroidal anti-inflammatory agents.

ADVERSE EFFECTS

Effects from digestive system: dyspepsia, nausea, vomiting, abdominal pains, constipation, meteorism, diarrhea, eructation, esophagitis, ulceration of stomach and duodenum, bleedings from GIT, transient changes of indices of liver function (increase in transminases activity or bilirubin plasma level), inflammation of oral cavity.
Effects from hematosis system: anemia, leukopenia, thrombocytopenia.
Effects from respiratory system: acute attack of asthma.
Effects from cardiovascular system: peripheral edemas, increase in blood pressure, palpitation, flushes.
Effects from CNS: headache and vertigo, tinnitus and somnolence, confusion of thoughts.
Effects from urinary organs: changes of indices of renal function (increase in creatinine level or/and blood urine).
Effects from vision organs: conjunctivitis, disorder of acuity of vision.
Dermatological reactions: itching, skin rash, urticaria, photosensitivity.

DOSAGE AND ADMINISTRATION

Loxidol is administrated in adults. Intramuscular administration is indicated only within first 2-3 days. Further treatment should be continued with per oral forms (tablets).
Recommended dosage is 15 mg once daily.
In patients with increased risk of adverse effects development treatment should be initiated with 7.5 mg dosage.

PREGNANCY AND LACTATION

Loxidol is contraindicated in pregnancy and lactation (breast-feeding).

3 ampoules with solution for IM injections 15 mg/1.5 ml in carton box with enclosed leaflet.

Musculo-Skeletal system

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