Doprokin-S
(Domperidone)




COMPOSITION

Each 5 ml of suspension contain 5 mg of domperidone and 20 mg of simethicone.

THERAPEUTIC INDICATIONS

- The sense of overfilling in epigastria, abdominal distension and bowels swilling, pain in upper part of a stomach.
- Eructation, meteorism.
- Nausea, vomiting.
- Pyrosis with or without reflux.
- Excessive gas-formation in postoperative period.
Preparation for gastroduodenoscopy, x-ray and instrumented abdominal and pelvic examination.

CONTRAINDICATIONS

Doprokin-S suspension is contraindicated for patients with known hypersensitivity to any drug compounds. Doprokin-S suspension should not be administered in case of gastrointestinal bleeding, mechanical bowel obstruction or perforation.

ADVERSE EFFECTS

Allergic reactions, such as skin rash and itching have been seldom reported. Extrapyramidal effects have been seldom observed in children and are not typical for adults. These effects are completely reversible and spontaneously disappear after the treatment cessation. The potential onset of neurological adverse effects cannot be completely excluded in case of insufficient development of blood-brain barrier (i.e. in children) or its dysfunction.

DOSAGE AND ADMINISTRATION

The recommended dose of Doprokin-S suspension for adults is 10-20 ml every 4-8 hours and for children is 5-10 ml every 4-8 hours. Doprokin-S suspension is prescribed 15-30 minutes before meal.

DRUG INTERACTIONS

Anticholinergic drugs can neutralize an antidyspeptic action of Doprokin-S suspension. Do not -administer antacid and antisecretory agents with Doprokin-S suspension as they decrease bioavailability of Domperidone following oral administration.

PREGNANCY AND LACTATION

Domperidone does not demonstrate a teratogenic action. Doprokin-S suspension should be administered during pregnancy only if the expected benefit justifies the potential risk to the fetus.
Domperidone concentration in human milk is 4 times less than the corresponding plasma concentrations. It is not known if this level takes a negative effect on infants. Therefore if a nursering mother administers Doprokin-S suspension, breast-feeding is not recommended, taking into account the importance of the drug to mother.

MANUFACTURED FORM

Suspension 60 ml in vials with a volumetric cap.

Alimentary Tract and Metabolism

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