Clavomed
(Amoxicilin & Clavulanic acid)




COMPOSITION

Each film coated tablet contains amoxicillin trihydate equivalent to 875 mg of amoxicillin, potassium clavulanate equivalent to 125 mg of clavulanic acid.

THERAPEUTIC INDICATIONS

 - Infections of upper air passages (acute and chronic sinusitis, acute and chronic middle otitis, tonsillitis- pharyngitis);
- Infections of lower air passages (acute and chronic bronchitis and pneumonia, pleural empyema);
- Infections of urinary tract (including cystitis, urethritis, pyelonephritis);
- Infections in gynaecology (including salpingitis, salpingo-oothecitis, endometritis, septic abortion, pelviperitonitis);
- Infections of bone and connective tissues (including chronic osteomyelitis);
- Infections of skin and soft tissues (including phlegmon, traumatic infection);
- Infections of biliary tracts (cholecystitis, cholangitis);
- Sexually transmitted diseases (gonorrhea, chancroid);
- Odontogenous infections;
- Prevention of infections at surgery.

CONTRAINDICATIONS

- Hypersensitivity to penicillin antibiotics;
- Cholestatic jaundice and hepatitis;
- Liver impairment;
- Infectious mononucleosis, lymphatic leukemia.

ADVERSE EFFECTS

Side effects in most cases are slight and temporary. Among registered side effects impairments of gastrointestinal tract have been reported most of all (appetite loss, nausea, vomiting, diarrhea). Unwished side effects can be avoided when Clavomed is taken during meal.

DRUG INTERACTIONS

Co-application of Clavomed suspension and methotrexate raises the toxicity of the last. The prescription with allopurinol raises the frequency of appearance skin rash (exanthema). In some cases Clavomed suspension can prolong the prothrombin time; in connection with it one should be cautious at concomitant prescription of anticoagulants and Clavomed. One should avoid the co-application with disulphiram. It is shown that antibiotics lower the effectiveness of peroral contraceptives. Probenecid lowers the elimination of amoxicillin, increasing its serum concentration.

PREGNANCY AND LACTATION

Either Amoxicillin or clavulanic acid in small quantities penetrate into breast milk, therefore breast feeding should be stopped during treatment with Clavomed. Clavomed may be taken during pregnancy, if supposed benefit for mother exceeds possible risk for fetus.

DOSAGE AND ADMINISTRATION

Adults and children over 12 years old:
Patients with severe infection should take Clavomed by one tablet 1.0 g twice a day.
Clavomed tablets for children younger 12 years old are not recommended.
Treatment with Clavomed can last for 14 days, after that patient should be examined by doctor.

MANUFACTURED FORM

Box with 10 tablets by 1.0 g.

Anti-─░nfectives for Systemic Use

All Products
Bactamed
Cefamed
Clavomed Suspension
Clavomed Tablet
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Fluzamed
Fosfomed
Levoximed Infusion
Levoximed Tablet
Lynozid
Merkacin
Orcipol
Ziromin

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